sars cov-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T77510	SARS-CoV-2-IN-46		SARS-CoV
	SARS-CoV-2-IN-46 is a SARS-CoV-2 inhibitor.		SARS-CoV
T77516	SARS-CoV-2-IN-39		Antiviral , SARS-CoV
	SARS-CoV-2-IN-39 is a SARS-CoV-2 inhibitor with an EC50 of 1 μM. SARS-CoV-2-IN-39 has antiviral activity and inhibits SARS-CoV-2 by inhibiting SKP2 protein and stabilizing BECN1.		Antiviral , SARS-CoV
T77652	SARS-CoV-2 3CLpro-IN-20		Antiviral , SARS-CoV
	SARS-CoV-2 3CLpro-IN-20 is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM,).SARS-CoV-2 3CLpro-IN-20 has potential antiviral activity.		Antiviral , SARS-CoV
T60538	SARS-CoV-2-IN-14	3',5-Dichlorosalicylanilide	SARS-CoV
	SARS-CoV-2-IN-14 is a potent and oral inhibitor of SARS-CoV-2 (IC50:0.39 μM), which is an analogue of niclosamide. SARS-CoV-2-IN-14 was more stable than niclosamide in the determination of human plasma and liver S9 enzym...		SARS-CoV
T9458	PF-00835231		SARS-CoV
	PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-00835231 is the active compound of the first anti-3CLpro regimen i...		SARS-CoV
T40207	SARS-CoV-2-IN-7
	SARS-CoV-2-IN-7 demonstrates potent inhibition of viral replication in SARS-CoV-2-infected Vero E6 cells with an IC50 value of 844 nM.
T38942	SARS-CoV-2-IN-9
	SARS-CoV-2-IN-9 is an inhibitor binding to subsites S1 and S2 in SARS-CoV-2 main protease.
T40340	SARS-CoV-2-IN-10
	SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral r...
T40341	SARS-CoV-2-IN-11
	SARS-CoV-2-IN-11 is a highly potent and non-toxic inhibitor of the 3C-like protease (3CLpro) of SARS-CoV-2, demonstrating IC50 and EC50 values of 0.17 nM and 1.45 nM, respectively. This compound targets the essential vir...
T12838	SARS-CoV-IN-2		Others
	SARS-CoV-IN-2 is an effective SARS-CoV replication inhibitor		Others
T36654	Anti-SARS-CoV-2 Spike mAb (CR3022)	Anti-SARS-CoV-2 Spike mAb (CR3022)
	Anti-SARS-CoV-2 Spike mAb (CR3022) is a human monoclonal IgG1 antibody derived from CHO cells. It specifically targets the S1 domain of the Spike protein in both SARS-CoV and SARS-CoV-2.
T12836	SARS-CoV-2-IN-1		Others
	SARS-CoV-2-IN-1 is a potent inhibitor of Mpro(SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively).		Others
T60919	SARS-CoV-2-IN-13		SARS-CoV
	SARS-CoV-2-IN-13 (compound 5) is an analogue of niclosamide. SARS-CoV-2-IN-13 is more stable than niclosamide in human plasma and liver S9 enzymes assay. SARS-CoV-2-IN-13 can improve bioavailability and half-life when ad...		SARS-CoV
T63098	SARS-CoV-2 Mpro-IN-2
	SARS-CoV-2 MPro-IN-2 is a selective, low cytotoxic, non-covalent Mpro inhibitor with an IC50 value of 0.40 μM. SARS-CoV-2 Mpro-IN-2 showed good anti-SARS-CoV-2 effect with EC50 value of 1.1 μM. SARS-CoV-2 Mpro-IN-2 can b...
T79659	SARS-CoV-2 3CLpro-IN-16		SARS-CoV
	SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.		SARS-CoV
T1817	GNF-2	GNF2	SARS-CoV , Bcr-Abl
	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.		SARS-CoV , Bcr-Abl
T7991	2-Hydroxycinnamic acid		Others , SARS-CoV , HIV Protease
	2-Hydroxycinnamic acid is a natural product isolated from Angraecum fragrans, has photooxidant activity.		Others , SARS-CoV , HIV Protease
T12502	PLpro inhibitor		SARS-CoV
	PLpro inhibitor is a potent papain-like protease (PLpro) inhibitor(IC50 of 2.6 uM)		SARS-CoV
T2486	IOWH-032	IOWH032,IOWH 032	CFTR , Autophagy
	IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.		CFTR , Autophagy
T9287	Hydroxychloroquine	2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol	SARS-CoV , TLR , Parasite , Autophagy
	Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It i...		SARS-CoV , TLR , Parasite , Autophagy